In 2007, Wisconsin had 232 drug arrests made by the Drug Enforcement Administration (DEA). Notably, in 2006, Wisconsin had a total of 4,203 juvenile and 15,605 adult arrests for drug possession.

In Wisconsin, both powder and crack cocaine can be easily accessed and remain of specific concern in the eastern and central areas of the state. There has also been an increase in the purity level of heroin in Wisconsin, granting users the alternative of snorting it instead of injecting it. Many younger users find this option particularly appealing.

In Wisconsin, marijuana continues to be easily accessible and is the most frequently abused drug in the state. The production and use of meth are growing from the Iowa and Minnesota (neighboring states) and are entering the northwest and southwest regions of Wisconsin. The majority of the meth found in Wisconsin is derived from Mexico; it is shipped from California and other states along the southwest border into Wisconsin. In Wisconsin diverted drugs remain an issue, with Ritalin, Vicodin, hydrocodone products, OxyContin, and benzodiazepines being the most illicit and diverted pharmaceuticals.

The Wisconsin Department of Justice, Division of Criminal Investigation: Narcotics Bureau assists in Wisconsin's war on drugs by giving investigative help to local law enforcement and starting private drug investigations. They target the three major organizations that control the majority of the transportation and wholesale distribution of drugs that are found in Wisconsin. These organizations include the Mexican drug trafficking organizations that ship cocaine, marijuana and meth; the Nigerian criminal organizations that are responsible for distributing Southeast Asian heroin; and the Dominican criminal organizations that handle the distribution of South American heroin and cocaine. In 2007, Federal agencies in Wisconsin apprehended 66,103 units of Ecstasy. Further, in 2007, Wisconsin had 4 meth lab incidents made by the DEA and state and local authorities. In 2006, under the DEA's Domestic Cannabis Eradication/Suppression Program, in excess of 8,000 marijuana plants were destroyed.

In 2006, 42.8 percent of the inmates serving a Federal sentence in Wisconsin had been found guilty of committing a drug violation; 39 percent of these cases were regarding crack cocaine. Notably, Wisconsin had 22,242 adult prisoners on January 25, 2008, declining from 72,473 in August 2007. The Wisconsin Division of Juvenile Corrections had 579 juvenile inmates on January 25, 2008.